TISSUES

Tissue expression database

USP51 tissues

USP51 [ENSP00000423333]

Ubiquitin-specific-processing protease 51; Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin.

Synonyms:  USP51,  USP51p,  hUSP51,  Q70EK9,  Q70EK9p ...

Linkouts:  STRING  Pharos  UniProt

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