Tissue expression database

ATG4D tissues

ATG4D [ENSP00000311318]

Autophagy-related cysteine endopeptidase 4; Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms; Belongs to the peptidase C54 family.

Synonyms:  ATG4D,  ATG4Dp,  hATG4D,  K7EKP6,  K7EMB9 ...

Linkouts:  STRING  Pharos

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