Tissue expression database

RNF157 tissues

RNF157 [ENSP00000269391]

RING-type E3 ubiquitin transferase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins

Synonyms:  RNF157,  RNF157p,  hRNF157,  K7EKB4,  Q96PX1 ...

Linkouts:  STRING  Pharos  UniProt

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