TISSUES

Tissue expression database

GRB14 tissues

GRB14 [ENSP00000263915]

Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal; Pleckstrin homology domain containing

Synonyms:  GRB14,  GRB14p,  hGRB14,  C9JD37,  C9JLT6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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