TISSUES

Tissue expression database

MAGEA3 tissues

MAGEA3 [ENSP00000473093]

Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes; MAGE family

Synonyms:  MAGEA3,  MAGEA3p,  hMAGEA3,  B9A060,  E7EMU0 ...

Linkouts:  STRING  Pharos  UniProt

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