TISSUES

Tissue expression database

KDM2A tissues

KDM2A [ENSP00000432786]

JmjC domain-containing histone demethylation protein 1A; Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Synonyms:  KDM2A,  KDM2Ap,  hKDM2A,  I3VM53,  I3VM54 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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