TISSUES

Tissue expression database

TNPO2 tissues

TNPO2 [ENSP00000407182]

Karyopherin beta-2b; Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity); Belongs to the importin beta family. Importin beta-2 subfamily.

Synonyms:  TNPO2,  TNPO2p,  hTNPO2,  A0A024R7F7,  K7EMA3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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