Non-canonical poly(A) RNA polymerase PAPD5; Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion; Belongs to the DNA polymerase type-B-like family.
Synonyms: PAPD5, PAPD5p, hPAPD5, B4DRJ7, B7ZLC1 ...