Tissue expression database

APOBEC3H tissues

APOBEC3H [ENSP00000385741]

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H- var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons; Apolipoprotein B mRNA editing enzyme catalytic subunits

Synonyms:  APOBEC3H,  APOBEC3H-001,  APOBEC3H-002,  APOBEC3H-003,  APOBEC3H-004 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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