Tissue expression database

GATSL3 tissues

GATSL3 [ENSP00000384183]

Cytosolic arginine sensor for mTORC1 subunit 1; Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1- containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway; Belongs to the GATS family.

Synonyms:  GATSL3,  GATSL3p,  hGATSL3,  B7WPJ3,  CASTOR1 ...

Linkouts:  STRING  Pharos  UniProt

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