DKK3 tissues
DKK3 [ENSP00000379762]
Dickkopf WNT signaling pathway inhibitor 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity); Belongs to the dickkopf family.
Synonyms: DKK3, DKK3p, hDKK3, DKK3-001, DKK3-002 ...