Tissue expression database

DKK3 tissues

DKK3 [ENSP00000379762]

Dickkopf WNT signaling pathway inhibitor 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity); Belongs to the dickkopf family.

Synonyms:  DKK3,  DKK3p,  hDKK3,  DKK3-001,  DKK3-002 ...

Linkouts:  STRING  Pharos  UniProt

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