SOCS4 tissues
SOCS4 [ENSP00000378855]
Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR; SH2 domain containing
Synonyms: SOCS4, SOCS4p, hSOCS4, DKFZP686J1568, Q5H9R6 ...