Tissue expression database

E2F4 tissues

E2F4 [ENSP00000368686]

E2F transcription factor 4, p107/p130-binding; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis; Belongs to the E2F/DP family.

Synonyms:  E2F4,  E2F4p,  hE2F4,  A0A024R6W7,  H3BMP3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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