Tissue expression database

IRG1 tissues

IRG1 [ENSP00000366682]

Immunoresponsive 1 homolog (mouse); Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

Synonyms:  IRG1,  IRG1p,  hIRG1,  A6NK06,  ACOD1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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