TISSUES

Tissue expression database

TRIM27 tissues

TRIM27 [ENSP00000366404]

RING-type E3 ubiquitin transferase TRIM27; E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double- stranded DNA; Ring finger proteins

Synonyms:  TRIM27,  TRIM27p,  hTRIM27,  RFP,  RNF76 ...

Linkouts:  STRING  Pharos  OMIM

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