Tissue expression database

CLIC4 tissues

CLIC4 [ENSP00000363500]

Intracellular chloride ion channel protein p64H1; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

Synonyms:  CLIC4,  CLIC4p,  hCLIC4,  B4DWC4,  Q6FIC5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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