TISSUES

Tissue expression database

PCGF6 tissues

PCGF6 [ENSP00000358862]

Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.

Synonyms:  PCGF6,  PCGF6p,  hPCGF6,  Q9BYE7,  MBLR ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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