TISSUES

Tissue expression database

PROX1 tissues

PROX1 [ENSP00000355925]

Homeobox prospero-like protein PROX1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3; Belongs to the Prospero homeodomain family.

Synonyms:  PROX1,  PROX1p,  hPROX1,  B4DP41,  C9JU29 ...

Linkouts:  STRING  Pharos  UniProt

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