TISSUES

Tissue expression database

CDC42BPA tissues

CDC42BPA [ENSP00000355731]

Myotonic dystrophy kinase-related CDC42-binding kinase alpha; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.

Synonyms:  CDC42BPA,  F5H5N0,  Q5VT25,  Q9H5K7,  Q9NYF6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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