Tissue expression database

UBA3 tissues

UBA3 [ENSP00000354340]

NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.

Synonyms:  UBA3,  UBA3p,  hUBA3,  B7Z5F6,  F8W8D4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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