TISSUES

Tissue expression database

DNAJB12 tissues

DNAJB12 [ENSP00000345575]

DnaJ (Hsp40) homolog, subfamily B, member 12; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70. When overexpressed, forms membranous structures together with DNAJB14 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear.

Synonyms:  DNAJB12,  DNAJB12p,  hDNAJB12,  DKFZP586B2023,  J3KPS0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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