Tissue expression database

PIDD1 tissues

PIDD1 [ENSP00000337797]

Leucine-rich repeat and death domain-containing protein; Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways.

Synonyms:  PIDD1,  PIDD1p,  hPIDD1,  E9PPT6,  Q9HB75 ...

Linkouts:  STRING  Pharos  UniProt

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