TISSUES

Tissue expression database

NR2C1 tissues

NR2C1 [ENSP00000333275]

Nuclear receptor subfamily 2, group C, member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation.

Synonyms:  NR2C1,  NR2C1p,  hNR2C1,  H9NIM2,  H9NIM3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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