Tissue expression database

PPM1A tissues

PPM1A [ENSP00000327255]

Protein phosphatase, Mg2+/Mn2+ dependent, 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family.

Synonyms:  PPM1A,  PPM1Ap,  hPPM1A,  A0A024R6A5,  E9PJN3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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