TISSUES

Tissue expression database

RBBP6 tissues

RBBP6 [ENSP00000317872]

P53-associated cellular protein of testis; E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10- dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication; Ring finger proteins

Synonyms:  RBBP6,  RBBP6p,  hRBBP6,  H3BSK8,  H3BUN0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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