TISSUES

Tissue expression database

ZBTB4 tissues

ZBTB4 [ENSP00000307858]

Zinc finger and BTB domain-containing protein 4; Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity); BTB domain containing

Synonyms:  ZBTB4,  ZBTB4p,  hZBTB4,  B3KVD4,  Q9P1Z0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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