TISSUES

Tissue expression database

TPX2 tissues

TPX2 [ENSP00000300403]

Differentially expressed in cancerous and non-cancerous lung cells 2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin- alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.

Synonyms:  TPX2,  TPX2p,  hTPX2,  B3KM90,  HCA90 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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