Tissue expression database

CHP2 tissues

CHP2 [ENSP00000300113]

Hepatocellular carcinoma-associated antigen 520; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus; EF-hand domain containing

Synonyms:  CHP2p,  hCHP2,  O43745,  HCA520,  O43745p ...

Linkouts:  STRING  Pharos  UniProt

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