Tissue expression database

RNF169 tissues

RNF169 [ENSP00000299563]

RING-type E3 ubiquitin transferase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair; Ring finger proteins

Synonyms:  RNF169,  RNF169p,  hRNF169,  Q8NCN4,  KIAA1991 ...

Linkouts:  STRING  Pharos  UniProt

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