TISSUES

Tissue expression database

MCM6 tissues

MCM6 [ENSP00000264156]

Minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.

Synonyms:  MCM6,  MCM6p,  hMCM6,  MCM6-001,  MCM6-002 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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