TISSUES

Tissue expression database

KAT2B tissues

KAT2B [ENSP00000263754]

Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers; Belongs to the acetyltransferase family. GCN5 subfamily.

Synonyms:  KAT2B,  KAT2Bp,  hKAT2B,  Q92831,  Q92831p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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