TISSUES

Tissue expression database

HACE1 tissues

HACE1 [ENSP00000262903]

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB; Ankyrin repeat domain containing

Synonyms:  HACE1,  HACE1p,  hHACE1,  E3W983,  E5RFX0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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