TISSUES

Tissue expression database

DOCK10 tissues

DOCK10 [ENSP00000258390]

Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression; Belongs to the DOCK family.

Synonyms:  DOCK10,  DOCK10p,  hDOCK10,  F8WB48,  F8WE73 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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