Tissue expression database

EDEM1 tissues

EDEM1 [ENSP00000256497]

ER degradation-enhancing alpha-mannosidase-like protein 1; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2; Belongs to the glycosyl hydrolase 47 family.

Synonyms:  EDEM1,  EDEM1p,  hEDEM1,  A0A024R2D5,  B4DXP3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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