TISSUES

Tissue expression database

MICAL2 tissues

MICAL2 [ENSP00000256194]

Microtubule associated monooxygenase, calponin and LIM domain containing 2; Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A- dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA; LIM domain containing

Synonyms:  MICAL2,  MICAL2p,  hMICAL2,  E9PJB0,  E9PKI3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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