TISSUES

Tissue expression database

MKRN1 tissues

MKRN1 [ENSP00000255977]

RING-type E3 ubiquitin transferase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription; Ring finger proteins

Synonyms:  MKRN1,  MKRN1p,  hMKRN1,  C9IY57,  C9IZP5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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