TISSUES

Tissue expression database

AKAP10 tissues

AKAP10 [ENSP00000225737]

Dual specificity A kinase-anchoring protein 2; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity); A-kinase anchoring proteins

Synonyms:  AKAP10,  AKAP10p,  hAKAP10,  AKAP10-001,  AKAP10-003 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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