TISSUES

Tissue expression database

RIPK3 tissues

RIPK3 [ENSP00000216274]

Receptor-interacting serine/threonine-protein kinase 3; Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Synonyms:  RIPK3,  RIPK3p,  hRIPK3,  Q9Y572,  Q9Y572p ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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