TISSUES

Tissue expression database

CBX7 tissues

CBX7 [ENSP00000216133]

Chromobox protein homolog 7; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity; Chromobox family

Synonyms:  CBX7,  CBX7p,  hCBX7,  A0A024R1M4,  A0A024R1Q2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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