PPP1R15A tissues
PPP1R15A [ENSP00000200453]
Myeloid differentiation primary response protein MyD116 homolog; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Synonyms: PPP1R15A, O75807, PPP1R15A-001, PPP1R15A-005, GADD34 ...