TISSUES

Tissue expression database

PPP1R15A tissues

PPP1R15A [ENSP00000200453]

Myeloid differentiation primary response protein MyD116 homolog; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.

Synonyms:  PPP1R15A,  O75807,  PPP1R15A-001,  PPP1R15A-005,  GADD34 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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