TISSUES

Tissue expression database

FSTL3 tissues

FSTL3 [ENSP00000166139]

Follistatin-like 3 (secreted glycoprotein); Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Synonyms:  FSTL3,  FSTL3p,  hFSTL3,  A0A024R1Y8,  FSTL3-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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