TISSUES

Tissue expression database

NABP1 tissues

NABP1 [ENSP00000403683]

Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.

Synonyms:  NABP1,  NABP1p,  hNABP1,  F8WAF5,  Q96AH0 ...

Linkouts:  STRING  Pharos  UniProt

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