TISSUES

Tissue expression database

ALOX15B tissues

ALOX15B [ENSP00000369530]

Arachidonate 15-lipoxygenase type II; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells; Arachidonate lipoxygenases

Synonyms:  ALOX15B,  ALOX15Bp,  hALOX15B,  I3L1D5,  O15296 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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