TISSUES

Tissue expression database

CNDP2 tissues

CNDP2 [ENSP00000325548]

CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. An elevated level of CNDP2 activates the p38 and JNK MAPK pathways to induce cell apoptosis, and a lower level of CNDP2 activates the ERK MAPK pathway to promote cell proliferation. Isoform 2 may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis; Belongs to the peptidase M20A family.

Synonyms:  CNDP2,  CNDP2p,  hCNDP2,  B4DV28,  HEL-S-13 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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