TISSUES

Tissue expression database

RNF139 tissues

RNF139 [ENSP00000304051]

Translocation in renal carcinoma on chromosome 8 protein; E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor; Ring finger proteins

Synonyms:  RNF139,  RNF139p,  hRNF139,  E5RH85,  Q8WU17 ...

Linkouts:  STRING  Pharos  UniProt  OMIM

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