TISSUES

Tissue expression database

ALKBH8 tissues

ALKBH8 [ENSP00000397673]

S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8; Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis; Alkylation repair homologs

Synonyms:  ALKBH8,  ALKBH8p,  hALKBH8,  C9JQN2,  Q96BT7 ...

Linkouts:  STRING  Pharos  UniProt

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