Rap guanine nucleotide exchange factor (GEF) 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Synonyms: RAPGEF1, RAPGEF1p, hRAPGEF1, DKFZP781P1719, Q13905 ...