TISSUES

Tissue expression database

JensenLab

NR1H2 tissues

NR1H2 [ENSP00000499121]

Oxysterols receptor LXR-beta; Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity . Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex .

Synonyms:  NR1H2,  NR1H2p,  hNR1H2,  M0QYE6,  M0QZF5 ...

Linkouts:  STRING  Pharos  UniProt

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