TISSUES

Tissue expression database

JensenLab

FAS tissues

FAS [ENSP00000498466]

Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Synonyms:  A0A087WTM9,  H7C5Z8,  K9J972,  P25445,  H7C5Z8p ...

Linkouts:  STRING  Pharos  UniProt

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