GNAI1 tissues
GNAI1 [ENSP00000497260]
Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins . Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis . Required for cortical dynein-dynactin complex recruitment during metaphase . ECO:0000269|PubMed:17635935, ECO:0000269|PubMed:18434541,; Belongs to the G-alpha family. G(i/o/t/z) subfamily.
Synonyms: GNAI1, GNAI1p, hGNAI1, A0A3B3IRK0, A0A3B3IS42 ...